In the United States alone, 1.25 million people suffer from type 1 diabetes. A vaccine used over 100 years ago for tuberculosis (bacillus Calmette-Guerin ) has shown promise in reversing this disease. This vaccine is now commonly used for treating bladder cancer and is considered to be safe.
An announcement made yesterday at the 75th Scientific Sessions of the American Diabetes Association said that the FDA will test the vaccine on 150 people who are in an advanced stage of type one diabetes.Follow @newslexpoint
The body of a person with type 1 diabetes
This does not produce insulin due to the immune system destroying the cells that create insulin. T cells are produced, and these cells create problems in the pancreatic islets, where insulin is produced. The vaccine works by eliminating these T cells.
Patients with diabetes injected with the vaccine saw an increase in the levels of a substance called tumor necrosis factor. The increased level of TNF in the system destroys the T cells that are hindering the production of insulin.
In a previous trial, patients were injected with the tuberculosis vaccine twice within a four-week time frame. The results showed that the dangerous T cells were gone, and some people even began to secrete insulin on their own.
“In the phase I (preliminary) trial we demonstrated a statistically significant response to BCG, but our goal in (this trial) is to create a lasting therapeutic response. We will be working again with people who have had type 1 diabetes for many years. This is not a prevention trial; instead, we are trying to create a regimen that will treat even advanced disease” explained Dr. Denise.
There’s a new trial coming which will use the same format as the previous one, on people at the age between 18 and 60. The subjects will be injected with the vaccine twice in a period of 4 weeks, and then once a year for a 4-year time span.
The Diabetes Care journal has published the results of a past study which analyzed the effects of Bacillus Calmette-Guerin (BCG) on kids with diabetes at the age between 5 and 18. The results showed that the BCG vaccine doesn’t keep the beta-cell function or raise the remission rate in kids.
Source: healthy and natural house
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